Thomson R G, Savan M
Can J Comp Med Vet Sci. 1963 Sep;27(9):207-14.
Outbreaks of virus diarrhea and mucosal disease were studied and certain clinical and pathological criteria applied in making a diagnosis of one or the other disease. An attempt was made to verify the diagnosis in each case by serological means in field outbreaks and by transmission of the disease experimentally in calves using post-mortem material.Serological studies in field outbreaks produced inconclusive results. Quite consistent results were obtained from transmission trials. Experimental calves developed diphasic temperature rises, leukopenia, and oral hyperemia with or without erosions. Specific antibody induced in experimental calves was capable of neutralizing the standard Oregon C24V strain of virus diarrhea. It was therefore apparent that the viral isolates obtained from nine outbreaks in this study were closely related. It was concluded that there were not two diseases, but one, and that according to priority should be called virus diarrhea.
对病毒性腹泻和黏膜病的暴发进行了研究，并应用某些临床和病理学标准来诊断这两种疾病中的一种。试图通过现场暴发时的血清学方法以及使用死后材料在犊牛身上进行疾病实验传播来在每个病例中验证诊断。现场暴发的血清学研究结果不明确。从传播试验中获得了相当一致的结果。实验性犊牛出现双相体温升高、白细胞减少以及伴有或不伴有糜烂的口腔充血。在实验性犊牛中诱导产生的特异性抗体能够中和病毒腹泻的标准俄勒冈C24V毒株。因此很明显，本研究中从9次暴发中分离得到的病毒密切相关。得出的结论是不存在两种疾病，而是一种疾病，并且根据优先权应称为病毒性腹泻。
