Rice C E, Silverstein A M
Can J Comp Med Vet Sci. 1964 Feb;28(2):34-7.
Determination of the haemolytic complement titres of serum from 24 foetal lambs bled at 77 to 149 days gestation failed to reveal this activity earlier than 123 days. Titres near the end of the gestation period of 150 days were still very low. Among serum specimens collected from 17 newborn lambs before suckling, three were still without demonstrable complement activity. During the first week titres rose considerably in all of these lambs, were higher at three weeks but at ten weeks were still below the adult level.A number of foeti had been injected with antigen mixtures at 50 to 111 days' gestation and had responded with antibody development to one or more of these antigens. The rate of development of complement in these treated foetal lambs appeared similar to that in their untreated twin controls.
对24只妊娠77至149天的胎羊采血，测定血清溶血补体滴度，结果显示在妊娠123天之前未发现这种活性。妊娠150天末期的滴度仍然很低。在17只新生羔羊哺乳前采集的血清样本中，有3只仍无明显的补体活性。在第一周，所有这些羔羊的滴度都大幅上升，三周时更高，但十周时仍低于成年水平。一些胎儿在妊娠50至111天时注射了抗原混合物，并对其中一种或多种抗原产生了抗体反应。这些经处理的胎羊补体的发育速度与其未经处理的双胞胎对照相似。
