Chen Yong-feng, Yang He-ping, Hu Jian-lin, Zhou Xiang-dong, Xiong Wei, Dai Xiao-tian, Li Xue-jun
Department of Respiratory, Xinan Hospital, Third Military Medical University, Chongqing 400038, China.
Zhonghua Yi Xue Za Zhi. 2007 Apr 3;87(13):921-3.
To investigate the expression of hypoxia inducible factor-1alpha (HIF-1alpha) and relationship thereof to survivin and Bax, apoptosis related proteins, in non-small cell lung cancer (NSCLC).
Immunohistochemistry was used in 52 specimens of NSCLC to detect the expression of HIF-1alpha, survivin and Bax.
The positive rates of HIF-1alpha, survivin and Bax were 38.5% (20/52), 48.1% (25/52), and 42.3% (22/52) respectively. The higher the pathological stage of tumor, the higher expression rate of HIF-1alpha (chi2=8.271, P<0.05). The positive rate of HIF-1alpha expression of the patients with lymph node metastasis was higher than that of the patients without lymph node metastasis (chi2=6.370, P<0.05). However, HIF-1alpha expression had no relationship to the pathological type (chi2=0.561, P>0.05) and differentiation degree (chi2=0.326, P>0.05). Correlation analysis showed that the expression of HIF-1alpha was positively correlated with the surviving expression (gamma=0.496, P<0.05) and Bax expression (gamma=0.681, P<0.05).
The expression of HIF-1alpha is related to the infiltration, metastasis, and apoptosis of NSCLC.
探讨缺氧诱导因子-1α（HIF-1α）在非小细胞肺癌（NSCLC）中的表达及其与凋亡相关蛋白生存素（survivin）和Bax的关系。
采用免疫组织化学法检测52例NSCLC标本中HIF-1α、survivin和Bax的表达。
HIF-1α、survivin和Bax的阳性率分别为38.5%（20/52）、48.1%（25/52）和42.3%（22/52）。肿瘤病理分期越高，HIF-1α表达率越高（χ2=8.271，P<0.05）。有淋巴结转移患者的HIF-1α表达阳性率高于无淋巴结转移患者（χ2=6.370，P<0.05）。然而，HIF-1α表达与病理类型（χ2=0.561，P>0.05）和分化程度（χ2=0.326，P>0.05）无关。相关性分析显示，HIF-1α表达与survivin表达呈正相关（γ=0.496，P<0.05），与Bax表达呈正相关（γ=0.681，P<0.05）。
HIF-1α的表达与NSCLC的浸润、转移及凋亡有关。
