单克隆丙种球蛋白病：采用回顾性方法研究其自然史。

Monoclonal gammopathy: natural history studied with a retrospective approach.

作者信息

Steingrimsdottir Hlif, Haraldsdottir Vilhelmìna, Olafsson Isleifur, Gudnason Vilmundur, Ogmundsdottir Helga M

机构信息

Landspitali University Hospital, Department of Clinical Hematology, Reykjavik, Iceland.

出版信息

Haematologica. 2007 Aug;92(8):1131-4. doi: 10.3324/haematol.11284.

DOI:10.3324/haematol.11284

PMID:17650445

Abstract

The aim of this study was to examine the natural history of monoclonal gammopathy using a retrospective approach and a long observation period. Protein electrophoresis (PE) and immunofixation (IF) was performed on frozen prediagnosis serum samples from 65 multiple myeloma (MM) and 10 Waldenström's macroglobulinemia (WM) cases. Paraprotein was found in 28% and 46% of the samples from cases using PE and IF respectively. The type of paraprotein was IgA in 33.4% of cases, IgG in 57%, and IgM in 8.5%. Excluding light chain or non-secretory disease, 72 % of MM cases had a prodromal MGUS phase within 10 years of diagnosis MM and WM were preceded by MGUS in at least half of the cases, confirming the premalignant nature of this condition.

摘要

本研究的目的是采用回顾性方法和较长的观察期来研究单克隆丙种球蛋白病的自然病史。对65例多发性骨髓瘤（MM）和10例华氏巨球蛋白血症（WM）病例的诊断前冷冻血清样本进行了蛋白质电泳（PE）和免疫固定（IF）检测。分别使用PE和IF在病例样本中发现副蛋白的比例为28%和46%。副蛋白类型为IgA的病例占33.4%，IgG的占57%，IgM的占8.5%。排除轻链或非分泌性疾病，72%的MM病例在诊断MM的10年内有前驱意义的意义未明的单克隆丙种球蛋白病（MGUS）阶段，至少一半的MM和WM病例之前有MGUS，证实了这种情况的癌前性质。