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维生素D受体基因多态性与非霍奇金淋巴瘤风险

Vitamin D receptor gene polymorphisms and risk of non-Hodgkin's lymphoma.

作者信息

Purdue Mark P, Lan Qing, Kricker Anne, Vajdic Claire M, Rothman Nathaniel, Armstrong Bruce K

出版信息

Haematologica. 2007 Aug;92(8):1145-6. doi: 10.3324/haematol.11053.

DOI:10.3324/haematol.11053
PMID:17650449
Abstract

We studied three vitamin D receptor gene (VDR) polymorphisms (BsmI, TaqI, FokI) in a case-control study of non-Hodgkin's lymphoma. The BsmI B and TaqI t alleles were associated with an increased risk of diffuse large B-cell lymphoma. These findings suggest that variants in VDR may influence lymphomagenesis.

摘要

在一项非霍奇金淋巴瘤的病例对照研究中,我们研究了三种维生素D受体基因(VDR)多态性(BsmI、TaqI、FokI)。BsmI B等位基因和TaqI t等位基因与弥漫性大B细胞淋巴瘤风险增加相关。这些发现表明,VDR中的变异可能影响淋巴瘤的发生。

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