Das Sujata, Constantinou Marios, Ong Terrence, Taylor Hugh R
Corneal Clinic, Royal Victorian Eye and Ear Hospital, and Centre for Eye Research Australia, Unviersity of Melbourne, Melbourne, Victoria, Australia.
Clin Exp Ophthalmol. 2007 Jul;35(5):427-31. doi: 10.1111/j.1442-9071.2007.01512.x.
To determine the predisposing risk factors and analyse the clinical and microbiological profiles of microbial keratitis following corneal transplantation.
A retrospective analysis was done of hospital records of all patients who presented with microbial keratitis in the corneal graft between July 2000 and June 2005 at the Corneal Unit of Royal Victorian Eye and Ear Hospital, Melbourne, Australia.
Eighty-one episodes of infection were identified in 62 patients over a 5-year period. Thirteen patients had multiple episodes of infection. The mean age of the patients was 70 +/- 16 years (range: 22-92 years). The median time interval between the graft and infection was 17 months (range: 6 days to 385 months). Twenty-two (35%) episodes of primary infection were related to sutures. The associated predisposing risk factors were failed graft (40%), dry eye (18%), Herpes simplex keratitis (8%), and ocular surface disease (8%). Forty-seven (76%) cases were culture positive for bacteria. Ten cases were positive for Herpes simplex virus (HSV) during presentation.
Failed graft is a long-term risk factor for graft infection in addition to ocular surface disease and H. simplex keratitis. All the predisposing risk factors increase the risk of recurrent graft infection.
确定角膜移植术后微生物性角膜炎的易感危险因素，并分析其临床和微生物学特征。
对2000年7月至2005年6月期间澳大利亚墨尔本皇家维多利亚眼耳医院角膜科所有出现角膜移植术后微生物性角膜炎患者的医院记录进行回顾性分析。
在5年期间，62例患者共发生81次感染发作。13例患者有多次感染发作。患者的平均年龄为70±16岁（范围：22 - 92岁）。移植与感染之间的中位时间间隔为17个月（范围：6天至385个月）。22次（35%）原发性感染发作与缝线有关。相关的易感危险因素包括移植失败（40%）、干眼（18%）、单纯疱疹性角膜炎（8%）和眼表疾病（8%）。47例（76%）细菌培养呈阳性。10例患者就诊时单纯疱疹病毒（HSV）检测呈阳性。
除眼表疾病和单纯疱疹性角膜炎外，移植失败是移植感染的长期危险因素。所有易感危险因素均增加了移植反复感染的风险。
