Besio Walter G, Koka Kanthaiah, Cole Andrew J
Department of Biomedical Engineering, Louisiana Tech University, Ruston, Louisiana 71272, USA.
Epilepsia. 2007 Dec;48(12):2273-9. doi: 10.1111/j.1528-1167.2007.01202.x. Epub 2007 Jul 25.
The aim of this pilot study was to investigate the antiepileptic effects of a novel noninvasive stimulation technique, transcutaneous electrical stimulation (TcES) via scalp concentric ring electrodes, on pilocarpine-induced status epilepticus (SE) in rats.
Five minutes after the onset of SE, TcES was administered to the experimental rat via bipolar concentric ring electrode at the CZ location. Symmetrical, biphasic, charge-balanced, constant current, isolated pulses were applied via a custom-made stimulator. TcES parameters ranged from 200-750 Hz, 200 or 300 mus pulse duration, and 50 or 60 mA, applied for 1 min, started with the least intense parameter set and progressively increased.
TcES attenuated electrographic seizure activity and halted the progression of behavioral seizures. Interruption of seizure activity outlasted the period of stimulation and appeared to be long-lasting. TcES treatment significantly extended the life and enhanced the survival of rats after SE.
Noninvasive TcES, applied 5 min after SE onset via novel concentric ring electrodes on the scalp, reduced, or abolished electrographic and behavioral seizure activity in pilocarpine-induced SE in rats. These findings suggest that TcES may have a role in the treatment of SE.
本初步研究旨在探讨一种新型非侵入性刺激技术，即通过头皮同心环电极进行经皮电刺激（TcES），对匹罗卡品诱导的大鼠癫痫持续状态（SE）的抗癫痫作用。
SE发作5分钟后，通过位于CZ位置的双极同心环电极对实验大鼠施加TcES。通过定制刺激器施加对称、双相、电荷平衡、恒流、隔离脉冲。TcES参数范围为200 - 750Hz、200或300μs脉冲持续时间以及50或60mA，持续1分钟，从强度最低的参数设置开始并逐渐增加。
TcES减弱了脑电图癫痫活动并阻止了行为性癫痫发作的进展。癫痫活动的中断持续时间超过刺激期，且似乎具有持久性。TcES治疗显著延长了SE后大鼠的寿命并提高了其存活率。
在SE发作5分钟后，通过头皮上新型同心环电极施加非侵入性TcES，可减少或消除匹罗卡品诱导的大鼠SE中的脑电图和行为性癫痫活动。这些发现表明TcES可能在SE治疗中发挥作用。
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