IEEE J Transl Eng Health Med. 2014 Jun 30;2:2000111. doi: 10.1109/JTEHM.2014.2332994. eCollection 2014.
Epilepsy is the second most prevalent neurological disorder ([Formula: see text]% prevalence) affecting [Formula: see text] million people worldwide with up to 75% from developing countries. The conventional electroencephalogram is plagued with artifacts from movements, muscles, and other sources. Tripolar concentric ring electrodes automatically attenuate muscle artifacts and provide improved signal quality. We performed basic experiments in healthy humans to show that tripolar concentric ring electrodes can indeed record the physiological alpha waves while eyes are closed. We then conducted concurrent recordings with conventional disc electrodes and tripolar concentric ring electrodes from patients with epilepsy. We found that we could detect high frequency oscillations, a marker for early seizure development and epileptogenic zone, on the scalp surface that appeared to become more narrow-band just prior to seizures. High frequency oscillations preceding seizures were present in an average of 35.5% of tripolar concentric ring electrode data channels for all the patients with epilepsy whose seizures were recorded and absent in the corresponding conventional disc electrode data. An average of 78.2% of channels that contained high frequency oscillations were within the seizure onset or irritative zones determined independently by three epileptologists based on conventional disc electrode data and videos.
癫痫是第二大常见的神经系统疾病（[公式：见文本]%的患病率），影响着全球[公式：见文本]百万人，其中多达 75%来自发展中国家。传统的脑电图受到运动、肌肉和其他来源的伪影的困扰。三极同心环电极自动衰减肌肉伪影并提供更好的信号质量。我们在健康人身上进行了基础实验，证明三极同心环电极确实可以在闭眼时记录生理阿尔法波。然后，我们同时用传统盘状电极和三极同心环电极从癫痫患者身上进行记录。我们发现，我们可以在头皮表面检测到高频振荡，这是早期癫痫发作和致痫区的标志物，在癫痫发作前似乎变得更窄带。在记录到癫痫发作的所有癫痫患者中，高频振荡在前癫痫发作中的出现频率平均为 35.5%的三极同心环电极数据通道中存在，而在相应的传统盘状电极数据中不存在。平均有 78.2%的包含高频振荡的通道位于根据传统盘状电极数据和视频由三位癫痫专家独立确定的癫痫发作起始区或刺激性区。
