鼠疫耶尔森菌CO92缺失yopH基因株是一种有效的减毒活鼠疫疫苗。
Yersinia pestis CO92 delta yopH is a potent live, attenuated plague vaccine.
作者信息
Bubeck Sarah S, Dube Peter H
机构信息
Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229, USA.
出版信息
Clin Vaccine Immunol. 2007 Sep;14(9):1235-8. doi: 10.1128/CVI.00137-07. Epub 2007 Jul 25.
Abstract
An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92 delta yopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.
摘要
鼠疫耶尔森氏菌CO92中yopH基因的框内缺失会减弱其在腺鼠疫和肺鼠疫模型中的毒力。当CO92 delta yopH用作减毒活疫苗时，它能为抵御鼠疫耶尔森氏菌CO92的亲本菌株攻击和呼吸道攻击提供高度保护。
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