鳞状细胞癌抗原在人宫颈癌中的临床意义。与癌胚抗原和糖类抗原125的比较。
Clinical significance of squamous cell carcinoma antigen in cancer of the human uterine cervix. Comparison with CEA and CA-125.
作者信息
Verlooy H, Devos P, Janssens J, Mortelmans L, Gerits M, Bonte J, De Roo M
机构信息
Department of Nuclear Medicine, University Hospital Gasthuisberg, Leuven, Belgium.
出版信息
Gynecol Obstet Invest. 1991;32(1):55-8. doi: 10.1159/000292993.
Serum squamous cell carcinoma antigen (SCCa) concentrations were determined by a radioimmunoassay kit before and during the treatment of 50 patients with cervical carcinoma: 44 with squamous cell carcinoma (SCC) and 6 with adenocarcinoma. The positivity rate of SCCa was 50% (52% for SCC and 33% for adenocarcinoma). The sensitivity of SCCa for SCC was twice as high as that of CEA and CA-125. Low serum concentrations were observed in early-stage carcinoma, indicating that SCCa is not useful for diagnosis. In advanced cases, serum levels were directly and significantly correlated with the stage of the disease.
采用放射免疫分析试剂盒测定了50例宫颈癌患者治疗前及治疗期间的血清鳞状细胞癌抗原（SCCa）浓度：其中44例为鳞状细胞癌（SCC），6例为腺癌。SCCa的阳性率为50%（SCC为52%，腺癌为33%）。SCCa对SCC的敏感性是癌胚抗原（CEA）和糖类抗原125（CA-125）的两倍。早期癌患者血清浓度较低，表明SCCa对诊断无帮助。在晚期病例中，血清水平与疾病分期直接且显著相关。
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