IgA肾病：超越IgA系膜沉积的免疫机制
IgA nephropathy: immune mechanisms beyond IgA mesangial deposition.
作者信息
Rifai A
机构信息
Department of Pathology and Laboratory Medicine, Lifespan Academic Medical Center, Brown University School of Medicine, Providence, Rhode Island, USA.
出版信息
Kidney Int. 2007 Aug;72(3):239-41. doi: 10.1038/sj.ki.5002356.
PMID:17653232
Abstract
IgA nephropathy is attributable to mesangial IgA immune complex deposition. The pathogenic potential of frequently colocalized IgG deposits may depend on polarized T-helper cytokines that modulate Fcgamma receptors of infiltrating macrophages, leading to either activation or inhibition that determines glomerular injury.
摘要
IgA肾病归因于系膜IgA免疫复合物沉积。频繁共定位的IgG沉积物的致病潜力可能取决于极化的辅助性T细胞细胞因子，这些细胞因子调节浸润巨噬细胞的Fcγ受体，导致决定肾小球损伤的激活或抑制。
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