[中国乙型肝炎病毒B基因型亚基因型的分布]
[Distribution of hepatitis B virus genotype B subgenotype in China].
作者信息
Huang Yue-hua, Zhou Bin, Wang Zhan-hui, Ma Shi-wu, Liang Min-feng, Hou Jin-lin
机构信息
Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
出版信息
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2007 Jun;21(2):111-3.
OBJECTIVE
To investigate the distribution of hepatitis B virus (HBV) genotype B subgenotype in China.
METHODS
A cohort of 511 patients with chronic HBV genotype B infection, collected from 7 centers across China, were analyzed by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or nucleotide sequencing.
RESULTS
For the 511 patients, only subgenotype Ba was identified and subgenotype Bj was not found.
CONCLUSION
In China, subgenotype Ba was the most prevalent HBV strains, while subgenotype Bj was very rarely found.
目的
研究中国乙型肝炎病毒（HBV）基因B型的亚型分布情况。
方法
采用聚合酶链反应-限制性片段长度多态性分析（PCR-RFLP）或核苷酸测序法，对来自中国7个中心的511例慢性HBV基因B型感染患者进行分析。
结果
在511例患者中，仅鉴定出Ba亚型，未发现Bj亚型。
结论
在中国，Ba亚型是最常见的HBV毒株，而Bj亚型非常罕见。
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