运动单位数量估计（MUNE）作为肌萎缩侧索硬化症疾病进展和运动单位重组的定量指标。

Motor unit number estimation (mune) as a quantitative measure of disease progression and motor unit reorganization in amyotrophic lateral sclerosis.

作者信息

Sartucci F, Maritato P, Moscato G, Orlandi G, Calabrese R, Domenici G L, Murri L

机构信息

Department of Neuroscience, Clinical Neurophysiology, Pisa University Medical School, Pisa, Italy.

出版信息

Int J Neurosci. 2007 Sep;117(9):1229-36. doi: 10.1080/00207450600936304.

DOI:10.1080/00207450600936304

PMID:17654089

Abstract

Motor Unit Number Estimation (MUNE), a technique allowing to estimate the number of functioning Motor Units (MU) in single muscles, was used to score the disease's severity and progression rate in a group of 58 patients with Amyotrophic Lateral Sclerosis (ALS). All patients underwent MUNE in the abductor digiti minimi (ADM) muscle during the diagnostic work-up (T0), after three (T1) and six (T2) months. A significant loss [p < .001] of MU and a decrease [p < .001] of the maximal M wave area at T0 was found, whereas mean step area was increased [p < .001]. During the follow-up (T1 and T2), MU loss continued, maximal M wave decreased, and mean step area increased significantly. The results confirm that MUNE is a suitable tool to quantify the pathological changes in MU in patients with ALS.

摘要

运动单位数量估计（MUNE）是一种可用于估计单块肌肉中功能性运动单位（MU）数量的技术，该技术被用于评估一组58例肌萎缩侧索硬化症（ALS）患者的疾病严重程度和进展速度。所有患者在诊断检查期间（T0）、三个月后（T1）和六个月后（T2）均接受了小指展肌（ADM）的MUNE检查。结果发现，在T0时运动单位有显著减少[p <.001]，最大M波面积减小[p <.001]，而平均步幅面积增加[p <.001]。在随访期间（T1和T2），运动单位持续丢失，最大M波减小，平均步幅面积显著增加。结果证实，MUNE是量化ALS患者运动单位病理变化的合适工具。