Zhdanov Vladimir P
Department of Applied Physics, Chalmers University of Technology, S-41296 Göteborg, Sweden.
J Chem Phys. 2007 Jul 21;127(3):035101. doi: 10.1063/1.2753159.
We show that the Monte Carlo technique makes it possible to perform three-dimensional simulations of intracellular protein-mediated signal transduction with realistic ratio of the rates of protein diffusion and association with genes. Specifically, we illustrate that in the simplest case when the protein degradation and phosphorylation/dephosphorylation are negligible the distribution of the first passage time for this process is close to exponential provided that the number of target genes is between 1 and 100.
我们表明，蒙特卡罗技术能够对细胞内蛋白质介导的信号转导进行三维模拟，且蛋白质扩散速率与基因结合速率的比例符合实际情况。具体而言，我们举例说明，在最简单的情况下，当蛋白质降解以及磷酸化/去磷酸化可忽略不计时，只要靶基因数量在1到100之间，该过程首次通过时间的分布就接近指数分布。
