Vistad I, Fosså S D, Kristensen G B, Dahl A A
Department of Gynaecology, Sorlandet Hospital HF, Kristiansand, Norway.
BJOG. 2007 Sep;114(9):1150-8. doi: 10.1111/j.1471-0528.2007.01445.x. Epub 2007 Jul 26.
To describe the prevalence of chronic fatigue (CF) and associated variables in locoregional cervical cancer survivors (CCSs) surveyed > 5 years after radiotherapy. Demographic, clinical and psychological characteristics of the CCSs were compared with normative data.
Cross-sectional study.
Department of Gynaecologic Oncology at Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway.
Seventy-nine CCSs aged < or = 79 years, treated between 1994 and 1999, representing 62% of those invited. Normative data were based on various population studies of Norwegian women.
Data were collected by means of a mailed questionnaire, which included demographic variables and instruments covering fatigue, mental distress, sexual functioning, somatic impairments and quality of life (QOL).
Self-reported fatigue score and caseness of CF based on the fatigue questionnaire.
CCSs showed 30% CF versus 13% reported in the general population (P= 0.001). CCSs with CF had a significantly lower QOL, higher levels of anxiety and depression and more physical impairments than those without CF. In a multivariable regression model, depression was the only variable significantly associated with CF in CCSs.
More CCSs have CF than age-matched women in the general population. CF should be of clinical concern since these women also frequently have treatable mental and physical problems.
描述放疗后5年以上接受调查的局部区域性宫颈癌幸存者（CCSs）中慢性疲劳（CF）的患病率及相关变量。将CCSs的人口统计学、临床和心理特征与标准数据进行比较。
横断面研究。
挪威奥斯陆Rikshospitalet-Radiumhospitalet医学中心妇科肿瘤学系。
79名年龄小于或等于79岁的CCSs，于1994年至1999年接受治疗，占受邀者的62%。标准数据基于对挪威女性的各种人群研究。
通过邮寄问卷收集数据，问卷包括人口统计学变量以及涵盖疲劳、精神困扰、性功能、躯体损伤和生活质量（QOL）的量表。
根据疲劳问卷得出的自我报告疲劳评分和CF病例情况。
CCSs中CF的患病率为30%，而普通人群中报告的患病率为13%（P = 0.001）。与无CF的CCSs相比，有CF的CCSs生活质量显著更低，焦虑和抑郁水平更高，躯体损伤更多。在多变量回归模型中，抑郁是CCSs中与CF显著相关的唯一变量。
与普通人群中年龄匹配的女性相比，更多的CCSs患有CF。由于这些女性还经常存在可治疗的心理和身体问题，CF应引起临床关注。
