Wallace Valerie A
Molecular Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada K1H 8L6.
Brain Res. 2008 Feb 4;1192:61-75. doi: 10.1016/j.brainres.2007.06.018. Epub 2007 Jun 16.
The retina is an excellent system for delving into the question of how cell fate, number and organization are regulated in the central nervous system. Multipotential progenitor cells in the immature retina proliferate, exit the cell cycle and generate neurons and one glial cell type in a prescribed temporal sequence. While some aspects of progenitor behavior are controlled cell intrinsically, extrinsic signals present in the retina environment have been shown to impact on proliferation, differentiation and cell fate of progenitors. Intercellular signaling proteins of the Hedgehog (Hh) family regulate several aspects of visual system development in vertebrates--ranging from early eye field patterning to retinal and optic nerve development. This review highlights the role of Hh signaling on retinal progenitor proliferation and diversification.
视网膜是研究中枢神经系统中细胞命运、数量和组织如何调控的绝佳系统。未成熟视网膜中的多能祖细胞增殖，退出细胞周期，并按规定的时间顺序生成神经元和一种神经胶质细胞类型。虽然祖细胞行为的某些方面受细胞内在控制，但视网膜环境中存在的外在信号已被证明会影响祖细胞的增殖、分化和细胞命运。刺猬（Hh）家族的细胞间信号蛋白调节脊椎动物视觉系统发育的多个方面——从早期眼场模式形成到视网膜和视神经发育。本综述重点介绍了Hh信号在视网膜祖细胞增殖和多样化中的作用。
