Zarrindast Mohammad R, Sattari-Naeini Manochehr, Khalilzadeh Azita
Department of Pharmacology and Iranian National Center for addiction Studies, Medical Sciences, University of Tehran, Iran.
Eur J Pharmacol. 2007 Nov 14;573(1-3):133-8. doi: 10.1016/j.ejphar.2007.06.044. Epub 2007 Jul 4.
In the present study, the effects of glucose and ATP-sensitive K+ channel compounds on the acquisition of morphine-induced place preference in male mice were investigated. Subcutaneous administration of different doses of morphine (2.5-7.5 mg/kg) produced a dose-dependent conditioned place preference. With a 3-day conditioning schedule, it was found that glucose (100, 200, 500 and 1000 mg/kg), diazoxide (15, 30 and 60 mg/kg) or glibenclamide (3, 6 and 12 mg/kg) did not produce significant place preference or place aversion. Intraperitoneal administration of the glucose (1000 mg/kg) or glibenclamide (6 and 12 mg/kg) with a lower dose of morphine (0.5 mg/kg) elicited the significant conditioned place preference. The response of glibenclamide (6 mg/kg) was reversed by diazoxide (15, 30 and 60 mg/kg). Drug injections had no effects on locomotor activity during the test sessions. It is concluded that glucose and the ATP-sensitive K+ channel may play an active role in morphine reward.
在本研究中，研究了葡萄糖和ATP敏感性钾通道化合物对雄性小鼠吗啡诱导的位置偏爱形成的影响。皮下注射不同剂量的吗啡（2.5 - 7.5毫克/千克）产生了剂量依赖性条件性位置偏爱。采用3天的条件化方案，发现葡萄糖（100、200、500和1000毫克/千克）、二氮嗪（15、30和60毫克/千克）或格列本脲（3、6和12毫克/千克）均未产生显著的位置偏爱或位置厌恶。腹腔注射葡萄糖（1000毫克/千克）或较低剂量吗啡（0.5毫克/千克）的格列本脲（6和12毫克/千克）引发了显著的条件性位置偏爱。二氮嗪（15、30和60毫克/千克）可逆转格列本脲（6毫克/千克）的反应。药物注射对测试期间的运动活动没有影响。得出的结论是，葡萄糖和ATP敏感性钾通道可能在吗啡奖赏中发挥积极作用。
