多靶点酪氨酸激酶抑制剂治疗后部分缓解的巩固性肾细胞癌转移灶切除术

Consolidative renal cell carcinoma metastatectomy for partial response after multitargeted tyrosine kinase inhibitor therapy.

作者信息

Neill Mischel G, Wei Alice C, Jewett Michael A S

机构信息

Department of Urologic Oncology, University Health Network, Toronto, Ontario, Canada.

出版信息

Urology. 2007 Jul;70(1):178.e9-11. doi: 10.1016/j.urology.2007.03.044.

DOI:10.1016/j.urology.2007.03.044

PMID:17656238

Abstract

The advent of molecularly targeted agents is rapidly changing the management of metastatic renal cell carcinoma. A case in which surgical metastatectomy was used in the setting of dramatic but incomplete disease response to sunitinib is presented. Some of the issues complicating operative intervention in the setting of multitargeted tyrosine kinase inhibitors are discussed.

摘要

分子靶向药物的出现正在迅速改变转移性肾细胞癌的治疗方式。本文介绍了一例在对舒尼替尼产生显著但不完全疾病反应的情况下进行手术切除转移灶的病例。文中还讨论了在多靶点酪氨酸激酶抑制剂治疗背景下使手术干预复杂化的一些问题。