一名变异型急性早幼粒细胞白血病患者中由标准t(15;17)逐步衍生而来的复杂易位。
Complex translocations derived stepwise from standard t(15;17) in a patient with variant acute promyelocytic leukemia.
作者信息
Miyazaki Kaori, Kikukawa Masayuki, Kiuchi Akihiro, Shin Kouichi, Iwamoto Toshihiko, Ohyashiki Kazuma
机构信息
Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
出版信息
Cancer Genet Cytogenet. 2007 Jul 15;176(2):127-30. doi: 10.1016/j.cancergencyto.2007.03.013.
We report the case of an elderly man with an acute promyelocytic leukemia variant carrying complex variant translocations. The Q-banded karyotype and spectral karyotyping method revealed a typical t(15;17), and two complex rearrangements caused by stepwise translocation derived from a typical t(15;17). Chromosomes 8 and 14 were related to these rearrangements. The patient received induction chemotherapy using all-trans retinoic acid and achieved complete remission. To our knowledge, a case with complex rearrangements, caused by apparent stepwise translocation, at diagnosis, has not been reported previously.
我们报告了一例患有急性早幼粒细胞白血病变异型且携带复杂变异易位的老年男性病例。Q带核型分析和光谱核型分析方法显示出典型的t(15;17)，以及由典型t(15;17)逐步易位导致的两个复杂重排。8号和14号染色体与这些重排有关。该患者接受了全反式维甲酸诱导化疗并实现了完全缓解。据我们所知，此前尚未报道过在诊断时因明显的逐步易位导致复杂重排的病例。
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