Molecular cytogenetic analysis of complex karyotypes with derivative chromosome der(1)t(1;5) found in two patients with myeloid leukemia. - Suppr | 超能文献

Molecular cytogenetic analysis of complex karyotypes with derivative chromosome der(1)t(1;5) found in two patients with myeloid leukemia.

作者信息

Melichercíková Jela, Brezinová Jana, Zemanová Zuzana, Cermák Jaroslav, Michalová Kyra

机构信息

Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, Czech Republic.

出版信息

Cancer Genet Cytogenet. 2007 Jul 15;176(2):150-5. doi: 10.1016/j.cancergencyto.2007.05.001.

DOI:10.1016/j.cancergencyto.2007.05.001

Abstract

Two patients with myeloid hematological malignancies were examined with conventional cytogenetic analysis, and complex chromosomal aberrations were found. Multicolor FISH (mFISH) was used to clarify these rearrangements. A similar translocation between chromosomes 1 and 5 was revealed in both patients. To specify breakpoints, high-resolution multicolor banding (mBAND) for chromosome 1 and chromosome 5 was performed. The breakpoints were resolved as der(1)t(1;5)(p21;p12) in patient 1 and as der(1)t(1;5)(p21;p11) in patient 2. The breakpoint on chromosome 1 was the same in both patients, in the 1p21 region. This region contains the colony stimulating factor 1 gene (CSF1), which may play a role in tumorigenesis of myeloid tissue.

摘要

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