Raaijmakers M H G P
Department of Hematology, University Medical Center Nijmegen St. Radboud, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands.
Leukemia. 2007 Oct;21(10):2094-102. doi: 10.1038/sj.leu.2404859. Epub 2007 Jul 26.
ATP-binding-cassette (ABC) transporters are evolutionary extremely well-conserved transmembrane proteins that are highly expressed in hematopoietic stem cells (HSCs). The physiological function in human stem cells is believed to be protection against genetic damage caused by both environmental and naturally occurring xenobiotics. Additionally, ABC transporters have been implicated in the maintenance of quiescence and cell fate decisions of stem cells. These physiological roles suggest a potential role in the pathogenesis and biology of stem cell-derived hematological malignancies such as acute and chronic myeloid leukemia. This paper reviews the (patho)physiological role of ABC transporters in human normal and malignant HSCs and discusses its implications for their utility as therapeutical targets to eradicate leukemic stem cells in these diseases.
ATP结合盒（ABC）转运蛋白是进化上高度保守的跨膜蛋白，在造血干细胞（HSC）中高表达。人们认为其在人类干细胞中的生理功能是保护细胞免受环境和天然存在的外源性物质所造成的遗传损伤。此外，ABC转运蛋白还与干细胞静止状态的维持以及细胞命运决定有关。这些生理作用提示了其在急性和慢性髓性白血病等干细胞源性血液系统恶性肿瘤的发病机制和生物学过程中可能发挥的作用。本文综述了ABC转运蛋白在人类正常和恶性造血干细胞中的（病理）生理作用，并讨论了将其作为治疗靶点以根除这些疾病中白血病干细胞的应用前景。
