Sashkov V A, Dzhandarova T I, Sel'verova N B
Institute of Aging Physiology, Russian Academy of Education, Moscow.
Neurosci Behav Physiol. 2007 Jul;37(6):623-9. doi: 10.1007/s11055-007-0061-0.
Interactions between the total blood calcium level and catecholamine contents in limbic brain structures during the formation and extinction of a conditioned passive avoidance reflex were studied in rats with hypoparathyroidism. Impairments of calcium support for the processes of conditioned reflex activity were seen after removal of the parathyroid glands. Animals with hypoparathyroidism not only showed changes in basal dopamine and noradrenaline levels in limbic structures, but also impairments of catecholamine dynamics during the acquisition and forced extinction of a conditioned passive avoidance reflex. These results demonstrate changes in the functional dynamics of the dopaminergic and noradrenergic systems of the brain in conditions of abnormal calcium homeostasis in the body, which underlie abnormalities of conditioned reflex activity and the acquisition of the adaptive behavioral strategies.
在甲状旁腺功能减退的大鼠中，研究了条件性被动回避反射形成和消退过程中全血钙水平与边缘脑结构中儿茶酚胺含量之间的相互作用。切除甲状旁腺后，可观察到钙对条件反射活动过程的支持作用受损。甲状旁腺功能减退的动物不仅边缘结构中基础多巴胺和去甲肾上腺素水平发生变化，而且在条件性被动回避反射的习得和强制消退过程中儿茶酚胺动力学也受损。这些结果表明，在机体钙稳态异常的情况下，大脑多巴胺能和去甲肾上腺素能系统的功能动力学发生变化，这是条件反射活动异常和适应性行为策略习得的基础。
