Laboratory Materials and Chemical Engineering, Faculty of Sciences, University of St-Etienne, St-Etienne, France.
Inflammopharmacology. 1998;6(4):321-37. doi: 10.1007/s10787-998-0016-2.
The drug level-time history in plasma and lung tissue was calculated with an antibiotic orally delivered in either an immediate-release or a controlled-release dosage form. The drug profiles were compared with experiment results given in the literature. In the same way, the drug level was evaluated in the bronchial secretion in contact with lung tissue. A numerical model, based on finite differences taking all the known facts into account was built and tested with the data found in the literature. Transport of the drug was looked at, including a stage of diffusion through the thickness of the lung tissue and a stage of convection into the bronchial secretion. A few parameters were thus considered, including the thickness of the lung tissue and the diffusivity of the antiobiotic through the tissue, the thickness of the bronchial secretion and the coefficient of convective transport into the sputum which characterizes its viscosity. Two partition factors were also introduced for the drug: between the tissue and the serum and between the lung tissue and the bronchial secretion.
以速释或控释剂型口服给予抗生素，计算其在血浆和肺组织中的药物时-浓度曲线。将药物浓度曲线与文献中的实验结果进行比较。同样，评估了与肺组织接触的支气管分泌物中的药物浓度。建立了一个基于有限差分的数值模型，考虑了所有已知事实，并使用文献中找到的数据进行了测试。研究了药物的传递，包括通过肺组织厚度的扩散阶段和进入支气管分泌物的对流阶段。因此，考虑了几个参数，包括肺组织的厚度和抗生素在组织中的扩散系数、支气管分泌物的厚度以及进入痰中的对流传输系数，这一系数反映了其粘性。还引入了两个药物分配因子：组织与血清之间以及肺组织与支气管分泌物之间。
