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BAG1和TIMP3在结肠癌中的临床病理意义

Clinicopathologic significance of BAG1 and TIMP3 expression in colon carcinoma.

作者信息

Bai Yu-Xian, Yi Ji-Lin, Li Jian-Feng, Sui Hong

机构信息

Department of Medicine, Affiliated Tumor Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China.

出版信息

World J Gastroenterol. 2007 Jul 28;13(28):3883-5. doi: 10.3748/wjg.v13.i28.3883.

DOI:10.3748/wjg.v13.i28.3883
PMID:17657847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4611225/
Abstract

AIM

To explore the expression of BAG1 and tissue inhibitor of metalloproteinase 3 (TIMP3) in colon carcinoma and their correlation and clinicopathologic significance.

METHODS

SABC immunohistochemistry was used to detect the expression of BAG1 and TIMP3 in 80 colon carcinoma tissues and 20 normal colonic mucosa.

RESULTS

Positive rate of BAG1 in colon carcinoma tissue (80%) was notably higher compared to normal colonic mucosa (10%) (P < 0.05). However, no significant difference was observed in positive rate of TIMP3 in colon carcinoma tissue (43.75%) as compared with normal colonic mucosa (60%) (P > 0.05). Expression of BAG1 and TIMP3 was strongly associated with colon carcinoma differentiation, Duke's staging, lymph node metastasis and survival rate (P < 0.05), but not associated with gender and age. Moreover, BAG1 expression was not correlated with TIMP3.

CONCLUSION

Our results suggest that over-expression of BAG1 or attenuated expression of TIMP3 may play an important role in genesis and development of colon carcinoma. The protein expression levels of BAG1 and TIMP3 are related to the malignant degree, infiltration and metastasis of colon carcinoma. BAG1 and TIMP3 might be new biological parameters in predicting invasion and metastasis of colon carcinoma.

摘要

目的

探讨BAG1和金属蛋白酶组织抑制剂3（TIMP3）在结肠癌中的表达及其相关性和临床病理意义。

方法

采用SABC免疫组织化学法检测80例结肠癌组织和20例正常结肠黏膜中BAG1和TIMP3的表达。

结果

结肠癌组织中BAG1的阳性率（80%）明显高于正常结肠黏膜（10%）（P<0.05）。然而，结肠癌组织中TIMP3的阳性率（43.75%）与正常结肠黏膜（60%）相比，差异无统计学意义（P>0.05）。BAG1和TIMP3的表达与结肠癌的分化程度、杜克分期、淋巴结转移及生存率密切相关（P<0.05），但与性别和年龄无关。此外，BAG1的表达与TIMP3无关。

结论

我们的结果表明，BAG1的过度表达或TIMP3的表达减弱可能在结肠癌的发生发展中起重要作用。BAG1和TIMP3的蛋白表达水平与结肠癌的恶性程度、浸润和转移有关。BAG1和TIMP3可能是预测结肠癌侵袭和转移的新生物学指标。

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