[通过利福平与碘化物及辣根根络合进行麻风病治疗的前景]
[Prospects for leprosy treatment via complexation of rifampicin witH iodide and horse-radish root].
作者信息
Maslov A K, Khivrina S A
出版信息
Probl Tuberk Bolezn Legk. 2007(4):25-7.
A model of leprosy was used to study the therapeutic effect of horse-radish root (HRR) containing peroxidase in combination with rifampicin (RFP) and potassium iodide (PI) as compared to routine combined therapy with RFP and diaminodiphenylsulfonum. Therapy with HRR and iodide showed the best antimicrobial effect than the routine combined therapy. A combination of RFP, HRR, and PI increased the activity of neutrophilic myeliperoxidase produced an anti-inflammatory activity and caused no persistent anemia or toxic effect on the murine liver.
利用麻风病模型研究了含过氧化物酶的辣根根（HRR）与利福平（RFP）和碘化钾（PI）联合使用的治疗效果，并与RFP和氨苯砜的常规联合治疗进行比较。与常规联合治疗相比，HRR和碘化物治疗显示出最佳的抗菌效果。RFP、HRR和PI的组合提高了嗜中性粒细胞髓过氧化物酶的活性，产生了抗炎活性，并且对小鼠肝脏没有持续的贫血或毒性作用。
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