Papalia T, Greco R, Mollica F, Cassani S, Bonofiglio R
U.O. di Nefrologia, Dialisi e Trapianto, Ospedale Annunziata, Cosenza.
G Ital Nefrol. 2007 Jul-Aug;24(4):333-7.
Sarcoidosis is a granulomatous disorder with multiorgan involvement which may appear in an isolated form but more often as a systemic disease. We report the case of a 53-year-old woman presenting with acute renal failure, hypercalcemia, elevated 1.25 dihydroxycholecalciferol, and a history of fatigue, weight loss and arthralgia of several months. Kidney biopsy had revealed interstitial noncaseating granulomas, so sarcoidosis was considered as a potential diagnosis after exclusion of other granulomatous disorders. Granulomatous tubulo-interstitial nephritis (GIN) is an uncommon disease with a low, but perhaps underestimated incidence: only about 100 cases have been described in the literature. In these cases it was found that the disease may lead to deterioration of renal function and irreversible progress to end-stage renal disease. The treatment of choice is the administration of steroids.
结节病是一种累及多器官的肉芽肿性疾病，可呈孤立形式出现，但更常表现为全身性疾病。我们报告一例53岁女性，表现为急性肾衰竭、高钙血症、1,25-二羟胆钙化醇升高，并有数月的疲劳、体重减轻和关节痛病史。肾脏活检显示间质非干酪样肉芽肿，排除其他肉芽肿性疾病后，结节病被视为一种可能的诊断。肉芽肿性肾小管间质性肾炎（GIN）是一种罕见疾病，发病率较低，但可能被低估：文献中仅描述了约100例。在这些病例中发现，该疾病可能导致肾功能恶化并不可逆转地进展为终末期肾病。治疗的首选是使用类固醇。
