弥漫型胃癌中8p22染色体区域频繁的杂合性缺失。
Frequent loss of heterozygosity at 8p22 chromosomal region in diffuse type of gastric cancer.
作者信息
Hosseini Hedayat Allah, Ahani Ali, Galehdari Hamid, Froughmand Ali Mohammad, Hosseini Masoud, Masjedizadeh Abdolrahim, Zali Mohammad Reza
机构信息
Biochemistry Department, Ahwaz Jondishapoor University of Medical Science, Ahwaz, Iran.
出版信息
World J Gastroenterol. 2007 Jun 28;13(24):3354-8. doi: 10.3748/wjg.v13.i24.3354.
AIM
To study the loss of heterozygosity (LOH) at 8p21-23 locus in diffuse gastric cancer.
METHODS
To evaluate the involvement of this region in gastric cancer, we used eight microsatellite markers covering two Mb of mentioned region, to perform a high-resolution analysis of allele loss in 42 cases of late diffuse gastric adenocarcinoma.
RESULTS
Six of these STS makers: D8S1149, D8S1645, D8S1643, D8S1508, D8S1591, and D8S1145 showed 36%, 28%, 37%, 41%, 44% and 53% LOH, respectively.
CONCLUSION
A critical region of loss, close to the NAT2 locus and relatively far from FEZ1 gene currently postulated as tumor suppressor gene in this region.
目的
研究弥漫性胃癌8p21 - 23位点的杂合性缺失（LOH）。
方法
为评估该区域在胃癌中的累及情况，我们使用了覆盖上述区域2兆碱基的8个微卫星标记，对42例晚期弥漫性胃腺癌进行等位基因缺失的高分辨率分析。
结果
其中6个序列标签位点（STS）标记：D8S1149、D8S1645、D8S1643、D8S1508、D8S1591和D8S1145的杂合性缺失分别为36%、28%、37%、41%、44%和53%。
结论
一个关键的缺失区域，靠近目前假定为该区域肿瘤抑制基因的NAT2位点且相对远离FEZ1基因。
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