DC-SIGN和甘露糖结合凝集素对HIV和SIV中和敏感性的调节作用
Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin.
作者信息
Marzi Andrea, Mitchell Daniel A, Chaipan Chawaree, Fisch Tanja, Doms Robert W, Carrington Mary, Desrosiers Ronald C, Pöhlmann Stefan
机构信息
Institute for Clinical and Molecular Virology, University Hospital Erlangen, 91054 Erlangen, Germany.
出版信息
Virology. 2007 Nov 25;368(2):322-30. doi: 10.1016/j.virol.2007.07.004. Epub 2007 Jul 30.
The C-type lectin DC-SIGN binds to oligosaccharides on the human and simian immunodeficiency virus (HIV, SIV) envelope glycoproteins and promotes infection of susceptible cells. Here, we show that DC-SIGN recognizes glycans involved in SIV sensitivity to neutralizing antibodies and that binding to DC-SIGN confers neutralization resistance to an otherwise sensitive SIV variant. Moreover, we provide evidence that mannose-binding lectin (MBL) can interfere with HIV-1 neutralization by the carbohydrate-specific antibody 2G12.
C型凝集素DC-SIGN可与人免疫缺陷病毒（HIV）和猴免疫缺陷病毒（SIV）包膜糖蛋白上的寡糖结合，并促进易感细胞的感染。在此，我们表明DC-SIGN可识别参与SIV对中和抗体敏感性的聚糖，并且与DC-SIGN的结合赋予原本敏感的SIV变体中和抗性。此外，我们提供证据表明甘露糖结合凝集素（MBL）可干扰碳水化合物特异性抗体2G12对HIV-1的中和作用。
Zotero 插件