Voigt K, Krämer U, Brügmann M, Dewar P, Sharp J M, Ganter M
Clinic for Swine, Small Ruminants, Forensic Medicine and Ambulatory Services, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, 30173 Hannover, Germany.
Vet Rec. 2007 Jul 28;161(4):129-32. doi: 10.1136/vr.161.4.129.
The principles of maedi-visna eradication programmes were applied to a field trial for the eradication of ovine pulmonary adenocarcinoma (OPA). In two maternal flocks the prevalence of gross and histological lesions in slaughtered animals was 18.3 per cent and 29.8 per cent, respectively. The lambing period was supervised for three consecutive years from 1999 to 2001, during which the lambs were taken away from their mothers at birth, deprived of maternal colostrum, and hand-reared away from other sheep. Over the three-year period, 322 hand-reared animals, mainly male lambs between 10 and 14 months old, were slaughtered; their lungs were examined grossly, 52.5 per cent of them were examined histologically, and 105 samples of caudal mediastinal lymph nodes were examined by PCR. No OPA tumours were detected in the slaughter specimens from the derived flock, but one lamb had histological lesions in one lung location; intrauterine transmission was ruled out in this case. No clinical OPA has subsequently been observed in the hand-reared flock. Bronchoalveolar lavage samples from the breeding stock were examined by PCR in order to rule out further subclinical cases of OPA. No Jaagsiekte retrovirus was detected in any of the 488 samples.
梅迪-维斯纳病根除计划的原则被应用于绵羊肺腺瘤（OPA）根除的田间试验。在两个母羊群中，屠宰动物的肉眼和组织学病变患病率分别为18.3%和29.8%。从1999年到2001年连续三年对产羔期进行监督，在此期间，羔羊出生时即与母亲分开，不喂初乳，并与其他绵羊分开人工饲养。在这三年期间，共屠宰了322只人工饲养的动物，主要是10至14个月大的雄性羔羊；对它们的肺进行了肉眼检查，其中52.5%进行了组织学检查，并对105份后纵隔淋巴结样本进行了PCR检测。在来自后代羊群的屠宰标本中未检测到OPA肿瘤，但有一只羔羊的一个肺部位出现了组织学病变；在这种情况下排除了宫内传播。随后在人工饲养的羊群中未观察到临床OPA病例。为了排除OPA的进一步亚临床病例，对种畜的支气管肺泡灌洗样本进行了PCR检测。在488份样本中均未检测到绵羊肺腺瘤逆转录病毒。
