Endo Itsuro, Matsumoto Toshio, Fukumoto Seiji
University of Tokushima Graduate School of Health Biosciences, Department of Medicine and Bioregulatory Sciences, Japan.
Clin Calcium. 2007 Aug;17(8):1175-81.
Hypoparathyroidism is characterized by decreased actions of parathyroid hormone (PTH) either by reduced secretion of or resistance to PTH. The understanding in the pathogenesis of hypoparathyroidism has been greatly increased by recent findings in genetic abnormalities of patients with hypoparathyroidism. A new classification of hypoparathyroidism based upon these genetic abnormalities is proposed, and a diagnostic approach to patients with hypoparathyroidism is summarized.
甲状旁腺功能减退症的特征是甲状旁腺激素(PTH)作用降低,原因是PTH分泌减少或对PTH产生抵抗。甲状旁腺功能减退症患者遗传异常的最新发现极大地增进了我们对其发病机制的理解。本文提出了基于这些遗传异常的甲状旁腺功能减退症新分类,并总结了甲状旁腺功能减退症患者的诊断方法。