Okazaki Ryo
Teikyo University Chiba Medical Center, Third Department of Medicine.
Clin Calcium. 2007 Dec;17(12):1852-7.
Hypoparathyoidism is classified into two categories: PTH deficient and PTH refractory (i.e. pseudohypoparathyrodism [PHP]). Bone metabolism is different between the two. In PTH deficient hypoparathyroidism such as post-operative hypoparathyroidism, BMD is increased with relatively low bone turnover markers. In PHP, which characterized by PTH resistance in proximal renal tubules, bone response to PTH is sometimes preserved. In some PHP cases, high bone turnover state is observed, which correlates with serum PTH levels.
甲状旁腺激素(PTH)缺乏型和PTH抵抗型(即假性甲状旁腺功能减退症[PHP])。两者的骨代谢情况有所不同。在PTH缺乏的甲状旁腺功能减退症中,如术后甲状旁腺功能减退症,骨密度(BMD)升高,骨转换标志物相对较低。在PHP中,其特征是近端肾小管对PTH有抵抗,骨对PTH的反应有时得以保留。在一些PHP病例中,观察到高骨转换状态,这与血清PTH水平相关。