Matsui H, Nishinaka K, Oda M, Niikawa H, Komatsu K, Kubori T, Udaka F
Department of Neurology, Sumitomo Hospital, Osaka, Japan.
Acta Neurol Scand. 2007 Aug;116(2):108-12. doi: 10.1111/j.1600-0404.2006.00795.x.
It is generally assumed that executive dysfunctions in Parkinson's disease (PD) are caused by degeneration of the basal ganglia or frontal cortex or both. However, there have been few studies investigating the relationship between executive dysfunctions and cerebral pathological change. The objective of this study was to evaluate various cognitive functions in non-demented patients with PD, and to compare the fractional anisotropy (FA) values of PD patients with and without executive dysfunction.
Twenty-one consecutive non-demented patients with PD were enrolled in this study. Patients were divided into two groups on the basis of their Wisconsin Card Sorting Test score.
There was significant FA reduction in the left parietal white matter in the group in which the number of categories achieved was <or=2 relative to the group that achieved >2.
Accumulating evidence suggests that conventional 'frontal' tasks correlate with both frontal lobe and parietal lobe function, and we suggest that pathological changes in the left parietal lobe may cause, in part, disturbances in executive tasks in PD.
一般认为帕金森病（PD）中的执行功能障碍是由基底神经节或额叶皮质或两者的退化引起的。然而，很少有研究调查执行功能障碍与脑病理变化之间的关系。本研究的目的是评估非痴呆型PD患者的各种认知功能，并比较有和没有执行功能障碍的PD患者的分数各向异性（FA）值。
本研究纳入了21例连续的非痴呆型PD患者。根据威斯康星卡片分类测试得分将患者分为两组。
相对于分类数>2的组，分类数≤2的组左侧顶叶白质的FA显著降低。
越来越多的证据表明，传统的“额叶”任务与额叶和顶叶功能均相关，并且我们认为左侧顶叶的病理变化可能部分导致PD患者执行任务的障碍。
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