Chen Kuan-Jen, Lin Ruey-Tay, Liu Ching-Kuan, Tai Chih-Ta, Lai Chiou-Lian
Graduate Institute of Behavioral Sciences and Department of Neurology, Kaohsiung Medical University, No. 100 Tzyou 1st Road, Kaohsiung 807, Taiwan.
Parkinsonism Relat Disord. 2006 Oct;12(7):453-8. doi: 10.1016/j.parkreldis.2006.04.008. Epub 2006 Jun 21.
Cognitive impairment in Parkinson's disease (PD) has been determined to be due to the interruption of frontal-subcortical neural circuits. To evaluate which kind of frontal-subcortical dysfunction may be present and the relationship of this dysfunction with P300 in PD patients, non-demented PD patients and controls were rendered for comprehensive Frontal Test Battery and P300 assessments. PD patients manifested significantly with frontal dysfunction and revealed a good correlation between P300 and executive dysfunction. We conclude that PD patients may manifest with cognitive impairment related to frontal dysfunction, and P300 may be an indicator reflecting the evolution of dysexecutive syndrome.
帕金森病（PD）中的认知障碍已被确定是由于额叶 - 皮质下神经回路的中断所致。为了评估PD患者可能存在哪种额叶 - 皮质下功能障碍以及这种功能障碍与P300的关系，对非痴呆PD患者和对照组进行了全面的额叶测试组合和P300评估。PD患者明显表现出额叶功能障碍，并且P300与执行功能障碍之间存在良好的相关性。我们得出结论，PD患者可能表现出与额叶功能障碍相关的认知障碍，并且P300可能是反映执行功能障碍综合征演变的一个指标。
