Smestad C, Brynedal B, Jonasdottir G, Lorentzen A R, Masterman T, Akesson E, Spurkland A, Lie B A, Palmgren J, Celius E G, Hillert J, Harbo H F
Department of Neurology, Ullevål University Hospital, Oslo, Norway.
Eur J Neurol. 2007 Aug;14(8):835-40. doi: 10.1111/j.1468-1331.2007.01825.x.
The human leucocyte antigen (HLA) class II haplotype DRB115-DQB106 (DR15-DQ6) is associated with susceptibility to multiple sclerosis (MS), and HLA class I associations in MS have also been reported. However, the influence of HLA class I and II alleles on clinical phenotypes in MS has not yet been completely studied. This study aimed at evaluating the impact of HLA-A and -DRB1 alleles on clinical variables in Scandinavian MS patients. The correlation between HLA-A or -DRB1 alleles and age at onset, disease course and Multiple Sclerosis Severity Score (MSSS) were studied in 1457 Norwegian and Swedish MS patients by regression analyses and Kruskal-Wallis rank sum test. Presence of HLA-DRB115 was correlated with younger age at onset of disease (corrected P = 0.009). No correlation was found between HLA-A and the variables studied. This study analysed the effect of HLA-A on clinical variables in a large Scandinavian sample set, but could not identify any significant contribution from HLA-A on the clinical phenotype in MS. However, associations between HLA-DRB115 and age at onset of MS were reproduced in this extended Scandinavian MS cohort.
人类白细胞抗原（HLA）II类单倍型DRB115 - DQB106（DR15 - DQ6）与多发性硬化症（MS）易感性相关，并且MS中HLA I类关联也已有报道。然而，HLA I类和II类等位基因对MS临床表型的影响尚未得到充分研究。本研究旨在评估HLA - A和 - DRB1等位基因对斯堪的纳维亚MS患者临床变量的影响。通过回归分析和Kruskal - Wallis秩和检验，对1457名挪威和瑞典MS患者的HLA - A或 - DRB1等位基因与发病年龄、病程和多发性硬化症严重程度评分（MSSS）之间的相关性进行了研究。HLA - DRB115的存在与疾病发病时较年轻的年龄相关（校正P = 0.009）。未发现HLA - A与所研究变量之间存在相关性。本研究分析了HLA - A对大量斯堪的纳维亚样本集中临床变量的影响，但未发现HLA - A对MS临床表型有任何显著贡献。然而，在这个扩大的斯堪的纳维亚MS队列中重现了HLA - DRB115与MS发病年龄之间的关联。
