Freitas Alessandra, Paz José Albino da, Casella Erasmo Barbante, Marques-Dias Maria Joaquina
Médica Pós-Graduanda do Setor de Neuropediatria do ICr, Mestre em Ciências pela FMUSP.
Arq Neuropsiquiatr. 2007 Jun;65(2B):381-4. doi: 10.1590/s0004-282x2007000300003.
Ketogenic diet (KD) is a high fat and low carbohydrate diet, which controls refractory epilepsy. We analyzed the KD effects on 54 children of the Children's Institute of the University of São Paulo. Efficacy, tolerability, and adverse effects were studied. Response to KD was effective (E) if seizure control was >75%, good (G) when 50-75%. When possible, we correlated the results with the epileptic syndrome and patient's age. By the second month on diet, 57.4% of the patients had E response and 31.4% G results. At the 6th month, 63.8% had E response and 25.5% G. At the 12th month, 71.8% had E and 25.6% G. At the 24th month, 62.1% had E and 37.9% G. Antiepileptic drugs have been reduced, and generalized epilepsy was the most sensitive. Age-related differences were not observed. Adverse effects were rarely observed. In conclusion, KD proved to be an effective treatment for refractory epilepsy.
生酮饮食（KD）是一种高脂肪、低碳水化合物的饮食，用于控制难治性癫痫。我们分析了生酮饮食对圣保罗大学儿童研究所54名儿童的影响。研究了其疗效、耐受性和不良反应。如果癫痫发作控制率>75%，则生酮饮食反应为有效（E）；当控制率为50%-75%时，反应为良好（G）。在可能的情况下，我们将结果与癫痫综合征和患者年龄相关联。在饮食的第二个月，57.4%的患者有有效反应，31.4%的患者反应良好。在第6个月时，63.8%的患者有有效反应，25.5%的患者反应良好。在第12个月时，71.8%的患者有有效反应，25.6%的患者反应良好。在第24个月时，62.1%的患者有有效反应，37.9%的患者反应良好。抗癫痫药物用量减少，全身性癫痫最为敏感。未观察到与年龄相关的差异。不良反应很少见。总之，生酮饮食被证明是治疗难治性癫痫的有效方法。
