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加巴喷丁治疗短时限单侧性神经痛性头痛发作并结膜充血及流泪综合征

[Gabapentin in the treatment of SUNCT syndrome].

作者信息

Rocha Filho Pedro Augusto Sampaio, Rabello Getulio D, Galvão Antonio C Ribeiro, Fortini Ida, Calderaro Marcelo, Carrocini Dalva

机构信息

Ambulatório de Cefaléias da Clínica Neurológica do Hospital das Clínicas da Universidade de São Paulo, São Paulo SP, Brasil.

出版信息

Arq Neuropsiquiatr. 2007 Jun;65(2B):503-5. doi: 10.1590/s0004-282x2007000300027.

Abstract

We report the cases of two women who presented a clinical condition compatible with the SUNCT (short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing) syndrome. Both presented normal clinical and neurological examination and MRI compatible with microangiopathy. The first one related headache attacks for three years, occurring several times a day when she masticated or yawned. She had a history of multiple failed therapies. The pain was controlled after the use of gabapetin (600 mg per day). The second one related she had daily headaches for six months that occurred from 20 to 40 times per day. At the first visit to the ambulatory, she related she was using carbamazepine (600 mg per day) and chlorpromazine (15 mg per day) having a partial response. Administration of gabapentin (1200 mg per day) led to complete resolution of the pain attacks, but the patient continue to have episodes of conjunctival injection.

摘要

我们报告了两名女性的病例,她们的临床症状与SUNCT(短暂性单侧神经痛样头痛发作伴结膜充血和流泪)综合征相符。两人的临床和神经系统检查均正常,MRI显示与微血管病变相符。第一名患者头痛发作三年,每天咀嚼或打哈欠时发作数次。她有多次治疗失败的病史。使用加巴喷丁(每天600毫克)后疼痛得到控制。第二名患者称她每天头痛六个月,每天发作20至40次。在首次到门诊就诊时,她称正在使用卡马西平(每天600毫克)和氯丙嗪(每天15毫克),有部分缓解。给予加巴喷丁(每天1200毫克)后疼痛发作完全缓解,但患者仍有结膜充血发作。

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