Grote H J, Schmiemann V, Kazimirek M, Böcking A
Institut für Cytopathologie, Universität Düsseldorf.
Pathologe. 2007 Sep;28(5):377-83. doi: 10.1007/s00292-007-0929-3.
Efficient, preferably early diagnosis of lung cancer represents a major challenge. Under this aspect the sensitivity of conventional histomorphology and cytomorphology procedures is unsatisfactory. This review highlights technical aspects, possibilities and drawbacks of the application of aberrant promoter methylation as a biomarker for lung cancer diagnostics using specimens of pulmonary exfoliative cytology.
高效，最好是早期诊断肺癌是一项重大挑战。在这方面，传统组织形态学和细胞形态学方法的敏感性并不令人满意。本综述重点介绍了将异常启动子甲基化作为肺癌诊断生物标志物，应用于肺脱落细胞学标本的技术方面、可能性和缺点。
