HLA - DRB1*0101与墨西哥梅斯蒂索人群患扁平苔藓的遗传易感性相关。
HLA-DRB1*0101 is associated with the genetic susceptibility to develop lichen planus in the Mexican Mestizo population.
作者信息
Luis-Montoya P, Yamamoto-Furusho J K, Vega-Memije E, Rodríguez-Carreón A, Ruiz-Morales J A, Vargas-Alarcón G, Domínguez-Soto L, Granados J
机构信息
Department of Dermatology, Hospital General Dr. Manuel Gea González, México D.F., Mexico.
出版信息
Arch Dermatol Res. 2007 Oct;299(8):405-7. doi: 10.1007/s00403-007-0769-2. Epub 2007 Jul 31.
The etiology of lichen planus (LP) is still unknown and previous studies have found an association between LP and HLA-DR1, DR2, DR3, DR9 and DR10 in different populations. The aim of this study was to analyze the distribution of the HLA-DRB1 alleles in Mexican Mestizo patients with LP. The aim of this study was to determine the gene frequency of HLA-DR locus in Mexican Mestizo patients with LP. We studied 20 patients with LP and 99 healthy Mexican Mestizo controls. HLA-DRB1 was performed by PCR-SSO reverse dot blot hybridization. High resolution HLA typing was performed by PCR-SSP. The HLA-DRB10101 allele was associated significantly in LP patients compared with healthy controls (pC = 0.0007, OR = 5.46, 95% CI = 1.86-16.06). HLA-DRB10101 is a marker for the development of LP in Mexican Mestizo population, yet another gene or HLA marker within MHC region may be the causatively associated gene.
扁平苔藓（LP）的病因仍然不明，先前的研究在不同人群中发现LP与HLA-DR1、DR2、DR3、DR9和DR10之间存在关联。本研究的目的是分析墨西哥梅斯蒂索LP患者中HLA-DRB1等位基因的分布情况。本研究的目的是确定墨西哥梅斯蒂索LP患者中HLA-DR位点的基因频率。我们研究了20例LP患者和99名健康的墨西哥梅斯蒂索对照。通过PCR-SSO反向斑点杂交法检测HLA-DRB1。通过PCR-SSP进行高分辨率HLA分型。与健康对照相比，LP患者中HLA-DRB10101等位基因有显著相关性（pC = 0.0007，OR = 5.46，95%CI = 1.86-16.06）。HLA-DRB10101是墨西哥梅斯蒂索人群中LP发病的一个标志物，但MHC区域内的另一个基因或HLA标志物可能是致病相关基因。
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