Rached-Amrouche Chiraz, Jamoussi-Kammoun Henda, BLouza-Chabchoub Samira
Unit of obesity, Tunisian National Institute of Nutrition.
Tunis Med. 2007 Feb;85(2):102-4.
Weight loss improves most of the comorbidities associated with obesity.
The purposes of this study are to determine the effects of dietary intervention and physical activity on weight management and to evaluate the beneficial effects of weight loss on metabolic profile of obese adults.
This prospective study concerned 24 obese and overweight patients recruited between 2003-2004. They have undergone a 6 months period of personalized diet and physical exercise.
Average weight loss achieved at 6 months was 6.8 +/- 5.6 kg (P < 10). Mean fat mass reduction was 3.05 +/- 6.2% (P = 0.02) and average waist circumference reduction was 7.55 +/- 5.21 cm (P < 10(-3)). This improvement in anthropometric parameters reduced significantly fasting glycaemia (-0.58 +/- 0.87 mmol/l, P = 0.01), total cholesterol levels (- 0.37 +/- 0.69 mmol/l, P = 0.03), triglyceridemia (- 0.39 +/- 0.45 mmol/ l, P = 0.004) and increased HDL-Cholesterol levels (+ 0.1 +/- 0.38 mmol/l, P = 0.05).
These results emphasize the urgent need to develop national strategies for the prevention and the management of overweight and obesity. Hence, we can improve metabolic abnormalities usually associated with obesity and reduce cardiovascular risk factors.
体重减轻可改善大多数与肥胖相关的合并症。
本研究的目的是确定饮食干预和体育活动对体重管理的影响，并评估体重减轻对肥胖成年人代谢状况的有益作用。
这项前瞻性研究涉及2003年至2004年间招募的24名肥胖和超重患者。他们接受了为期6个月的个性化饮食和体育锻炼。
6个月时的平均体重减轻为6.8±5.6千克（P<0.1）。平均脂肪量减少3.05±6.2%（P=0.02），平均腰围减少7.55±5.21厘米（P<0.001）。人体测量参数的这种改善显著降低了空腹血糖（-0.58±0.87毫摩尔/升，P=0.01）、总胆固醇水平（-0.37±0.69毫摩尔/升，P=0.03）、甘油三酯血症（-0.39±0.45毫摩尔/升，P=0.004），并提高了高密度脂蛋白胆固醇水平（+0.1±0.38毫摩尔/升，P=0.05）。
这些结果强调迫切需要制定国家战略来预防和管理超重及肥胖。因此，我们可以改善通常与肥胖相关的代谢异常，并降低心血管危险因素。
