Campisi Paolo, Allen Upton D, Ngan Bo-Yee, Hawkes Michael, Forte Vito
Department of Otolaryngology--Head and Neck Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Canada.
Otolaryngol Head Neck Surg. 2007 Aug;137(2):296-300. doi: 10.1016/j.otohns.2007.02.020.
To determine the diagnostic yield of head and neck biopsies in the evaluation of PTLD in children and to explore whether this yield was related to pretransplant Epstein-Barr virus (EBV) serostatus.
This is a retrospective study of pediatric, post-solid-organ transplant recipients who have undergone a biopsy in the head and neck region to establish a diagnosis of PTLD.
Fifty-six biopsies were performed in 46 patients four to 120 months after solid-organ transplantation. Biopsies yielded PTLD in 39.1% of patients. The odds of developing PTLD if a patient was seropositive for EBV at the time of transplantation was 0.26 (95% confidence interval, 0.064-1.056; P = 0.054).
The high diagnostic yield of PTLD suggests that biopsies should be performed if PTLD is suspected in pediatric posttransplant patients. The results demonstrate a trend toward lower risk of PTLD among patients with pretransplant exposure to EBV.
确定头颈部活检在儿童移植后淋巴组织增生性疾病（PTLD）评估中的诊断率，并探讨该诊断率是否与移植前爱泼斯坦-巴尔病毒（EBV）血清学状态相关。
这是一项针对实体器官移植术后接受头颈部活检以确诊PTLD的儿科患者的回顾性研究。
46例患者在实体器官移植后4至120个月进行了56次活检。活检确诊PTLD的患者占39.1%。移植时EBV血清学阳性的患者发生PTLD的几率为0.26（95%置信区间，0.064 - 1.056；P = 0.054）。
PTLD的高诊断率表明，对于疑似PTLD的儿科移植后患者应进行活检。结果显示移植前接触EBV的患者发生PTLD的风险有降低趋势。
