Frazier Jean A, McCLELLAN Jon, Findling Robert L, Vitiello Benedetto, Anderson Robert, Zablotsky Benjamin, Williams Emily, McNAMARA Nora K, Jackson Joseph A, Ritz Louise, Hlastala Stefanie A, Pierson Leslie, Varley Jennifer A, Puglia Madeline, Maloney Ann E, Ambler Denisse, Hunt-Harrison Tyehimba, Hamer Robert M, Noyes Nancy, Lieberman Jeffrey A, Sikich Linmarie
Drs. Frazier and Jackson, Mr. Zablotsky, and Ms. Noyes are with the Cambridge Health Alliance, Harvard Medical School, Cambridge, MA; Drs. McClellan and Hlastala, Ms. Pierson, and Ms. Varley are with the University of Washington, Seattle; Drs. Findling and McNamara are with the Case Western Reserve University, Cleveland; Dr. Vitiello and Ms. Ritz are with the National Institute of Mental Health, Bethesda, MD; Dr. Maloney is with the Maine Medical Center, Portland; Dr. Hunt-Harrison is with the John Umstead Hospital, Butner, NC; Dr. Lieberman is with Columbia University, New York; and Drs. Sikich, Hamer, and Ambler, Ms. Williams, Ms. Puglia, and Mr. Anderson are with the University of North Carolina at Chapel Hill..
Drs. Frazier and Jackson, Mr. Zablotsky, and Ms. Noyes are with the Cambridge Health Alliance, Harvard Medical School, Cambridge, MA; Drs. McClellan and Hlastala, Ms. Pierson, and Ms. Varley are with the University of Washington, Seattle; Drs. Findling and McNamara are with the Case Western Reserve University, Cleveland; Dr. Vitiello and Ms. Ritz are with the National Institute of Mental Health, Bethesda, MD; Dr. Maloney is with the Maine Medical Center, Portland; Dr. Hunt-Harrison is with the John Umstead Hospital, Butner, NC; Dr. Lieberman is with Columbia University, New York; and Drs. Sikich, Hamer, and Ambler, Ms. Williams, Ms. Puglia, and Mr. Anderson are with the University of North Carolina at Chapel Hill.
J Am Acad Child Adolesc Psychiatry. 2007 Aug;46(8):979-988. doi: 10.1097/chi.0b013e31807083fd.
We examined baseline demographic and clinical profiles of youths enrolled from 2001 to 2006 in the publicly funded multicenter, randomized controlled trial Treatment of Early-Onset Schizophrenia Spectrum Disorders.
Youths (8-19 years) with schizophrenia (SZ) and schizoaffective disorder were recruited at four academic sites. Diagnosis was made via structured and clinical interviews. Assessments of psychiatric symptoms and social and global functioning were included.
A total of 119 youths were enrolled. The mean age at illness onset was 11.1 +/- 3.5 years. Patients with SZ and schizoaffective disorder had similar ratings on the Positive and Negative Symptom Scale, Brief Psychiatric Rating Scale for Children, and Clinical Global Impression-Severity Scale. The overall level of functioning was similar in the two groups. A comparison to published reports of adults with SZ indicates that these youths may have more severe symptoms based on results of the Positive and Negative Symptom Scale.
This is one of the largest samples of youths with SZ spectrum disorders studied to date and the largest assessment of youths with schizoaffective disorder. High rates of symptoms and general psychopathology were noted. There was a substantial degree of social and functional impairment. The symptom profiles are consistent with, but more severe than, those reported in the adult literature.
我们研究了2001年至2006年参加公共资助的多中心随机对照试验“早发性精神分裂症谱系障碍治疗”的青少年的基线人口统计学和临床特征。
在四个学术地点招募了患有精神分裂症（SZ）和分裂情感性障碍的青少年（8至19岁）。通过结构化访谈和临床访谈进行诊断。包括对精神症状以及社会和整体功能的评估。
共招募了119名青少年。发病的平均年龄为11.1±3.5岁。精神分裂症患者和分裂情感性障碍患者在阳性和阴性症状量表、儿童简明精神病评定量表以及临床总体印象-严重程度量表上的评分相似。两组的整体功能水平相似。与已发表的成年精神分裂症患者报告相比，根据阳性和阴性症状量表的结果，这些青少年可能有更严重的症状。
这是迄今为止研究的患有精神分裂症谱系障碍青少年的最大样本之一，也是对患有分裂情感性障碍青少年的最大评估。注意到症状和一般精神病理学的高发生率。存在相当程度的社会和功能损害。症状特征与成人文献中报道的一致，但更为严重。
