Poggio Emilio D, Batty D Scott, Flechner Stuart M
Department of Nephrology and Hypertension and Transplant Center, Cleveland Clinic, Cleveland, OH 44195, USA.
Transplantation. 2007 Jul 27;84(2):131-6. doi: 10.1097/01.tp.0000269108.59275.dc.
Kidney dysfunction causes a myriad of adverse influences on posttransplant outcomes necessitating accurate assessment of kidney function for patient management. This evaluation assists in guiding treatment decisions, with the ultimate aim of allaying renal function decline. In clinical practice, renal function is typically estimated from serum creatinine levels, creatinine-based estimation equations or creatinine clearance; however, each of these methods has demonstrated limitations when used in the kidney transplant setting. Equally important is the emerging recognition of the incidence and impact of kidney dysfunction in recipients of nonrenal solid organ transplantation. The performance of commonly used estimation equations and methods for measuring kidney function in renal and liver transplant patients are overviewed here along with their potential roles in clinical transplantation.
肾功能障碍对移植后结局产生诸多不利影响，因此需要准确评估肾功能以进行患者管理。这种评估有助于指导治疗决策，其最终目的是减缓肾功能下降。在临床实践中，肾功能通常根据血清肌酐水平、基于肌酐的估算方程或肌酐清除率来估算；然而，这些方法在肾移植环境中使用时均显示出局限性。同样重要的是，人们越来越认识到非肾实体器官移植受者中肾功能障碍的发生率及其影响。本文概述了肾移植和肝移植患者中常用的估算方程及测量肾功能方法的性能，以及它们在临床移植中的潜在作用。
