Immunoglobulin e-mediated allergies in lung-transplanted adults.
作者信息
Gruber Saskia, Dehlink Eleonora, Eiwegger Thomas, Gut Susanne, Jaksch Peter, Klepetko Walter, Rumpold Helmut, Szépfalusi Zsolt
机构信息
Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
出版信息
Transplantation. 2007 Jul 27;84(2):275-9. doi: 10.1097/01.tp.0000268075.82161.9d.
BACKGROUND
Immunoglobulin E (IgE)-mediated allergy has repeatedly been reported after solid organ transplantation, apparently affecting approximately 10% of pediatric organ transplant recipients. Interestingly, type 1 allergy has not been described in transplanted adults, suggesting a particular propensity in childhood.
METHODS
The present cross-sectional study assessed the prevalence of type 1 allergy in 42 adult lung transplant recipients aged 25 to 50 years. Instruments included standardized interviews, skin prick tests, and serum IgE measurements.
RESULTS
Ten of 42 patients (23.8%) displayed elevated specific IgE levels or positive skin prick test results against one or more allergens. Five individuals (11.9%) additionally reported corresponding clinical symptoms of type 1 allergy. No statistically significant association of sensitization or allergy prevalence with patient age, kind of immunosuppressive therapy, and time since transplantation was found.
CONCLUSIONS
The phenomenon of transplantation-associated allergy is not age-restricted and thus should be assessed more thoroughly in all age groups.
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