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欧洲一例肺炎克雷伯菌肝脓肿并发内源性眼内炎的病例报告。

Endogenous endophthalmitis complicating Klebsiella pneumoniae liver abscess in Europe: case report.

作者信息

Karama Edison Mutsinzi, Willermain François, Janssens Xavier, Claus Marc, Van den Wijngaert Sigi, Wang Jim-Town, Verougstraete Claire, Caspers Laure

机构信息

Department of Ophthalmology, CHU St-Pierre and Brugmann, Université Libre de Bruxelles, Rue Haute 322, 1000 Bruxelles, Belgium.

出版信息

Int Ophthalmol. 2008 Apr;28(2):111-3. doi: 10.1007/s10792-007-9111-4. Epub 2007 Aug 1.

Abstract

PURPOSE

To report the first European case of endogenous endophthalmitis secondary to a liver abscess due to Klebsiella pneumoniae expressing MagA gene.

METHODS

A 33-year-old diabetic patient was admitted for fever and right upper quadrant abdominal pain. Abdominal computed tomography and laboratory studies were performed. On day 4 after admission, patient complained of a painful and red right eye with decreased vision. A complete ophthalmological examination, including visual acuity assessment, slit lamp examination and fundus ophthalmoscopy was started.

RESULTS

Klebsiella pneumoniae liver abscess was diagnosed and antibiotherapy initiated. Polymerase chain reaction revealed that the isolated Klebsiella pneumoniae was serotype K1 and positive for Mag A. Ophthalmological examination disclosed cells in the anterior chamber and an important vitritis. Fundus was barely visible. A diagnosis of Klebsiella pneumoniae endogenous endophthalmitis complicating liver abscess was made. Intravitreal injection of antibiotics resulted in a preservation of visual acuity.

CONCLUSION

This report suggests that rather than being confined to Taiwan, endogenous endophthalmitis secondary to a liver abscess due to Klebsiella pneumoniae expressing MagA gene, is becoming a global problem.

摘要

目的

报告欧洲首例因表达MagA基因的肺炎克雷伯菌引起肝脓肿继发的内源性眼内炎病例。

方法

一名33岁的糖尿病患者因发热和右上腹疼痛入院。进行了腹部计算机断层扫描和实验室检查。入院后第4天,患者主诉右眼疼痛、发红且视力下降。开始进行全面的眼科检查,包括视力评估、裂隙灯检查和眼底镜检查。

结果

诊断为肺炎克雷伯菌肝脓肿并开始抗生素治疗。聚合酶链反应显示,分离出的肺炎克雷伯菌为K1血清型且Mag A呈阳性。眼科检查发现前房有细胞以及严重的玻璃体炎。眼底几乎看不见。诊断为肺炎克雷伯菌内源性眼内炎并发肝脓肿。玻璃体内注射抗生素使视力得以保留。

结论

本报告表明,因表达MagA基因的肺炎克雷伯菌引起肝脓肿继发的内源性眼内炎并非仅限于台湾,正成为一个全球性问题。

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