丙咪嗪可逆转脓毒症存活大鼠的抑郁症状。
Imipramine reverses the depressive symptoms in sepsis survivor rats.
作者信息
Tuon Lisiane, Comim Clarissa M, Antunes Moises M, Constantino Larissa S, Machado Roberta A, Izquierdo Ivan, Quevedo João, Dal-Pizzol Felipe
机构信息
Laboratório de Neurociências, Programa de Pós-Graduação Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, Brazil.
出版信息
Intensive Care Med. 2007 Dec;33(12):2165-7. doi: 10.1007/s00134-007-0804-y. Epub 2007 Aug 1.
OBJECTIVE
To evaluate the antidepressant effect of imipramine on depressive symptoms observed in sepsis survivors rats.
DESIGN AND SETTING
Prospective, controlled experiment in an animal basic science laboratory.
SUBJECTS
Male Wistar rats weighing 300-350 g.
INTERVENTIONS
The rats underwent cecal ligation and perforation (CLP; sepsis group) with "basic support" (saline at 50 ml/kg immediately and 12 h after CLP plus ceftriaxone at 30 mg/kg and clindamycin at 25 mg/kg 6, 12, and 18 h after CLP) or sham-operated (control group). After 10 days of recovery rats received intraperitoneal injections of imipramine 10 mg/kg or saline and were subjected to the forced swimming test.
MEASUREMENTS AND RESULTS
The observed increase in the immobility time in the forced swimming test in animals subjected to CLP, as a parameter of depressive behavior, was reversed by imipramine.
CONCLUSIONS
The depressive symptoms evaluated by forced swimming test had been reversed after imipramine administration. Our data provide evidence that CLP-induced depressive symptoms are sensitive to antidepressants.
目的
评估丙咪嗪对脓毒症存活大鼠所观察到的抑郁症状的抗抑郁作用。
设计与环境
在动物基础科学实验室进行的前瞻性对照实验。
研究对象
体重300 - 350克的雄性Wistar大鼠。
干预措施
大鼠接受盲肠结扎穿孔术（CLP；脓毒症组）并给予“基础支持”（CLP术后即刻及术后12小时给予50毫升/千克生理盐水，CLP术后6、12及18小时给予30毫克/千克头孢曲松和25毫克/千克克林霉素），或进行假手术（对照组）。恢复10天后，大鼠接受腹腔注射10毫克/千克丙咪嗪或生理盐水，并进行强迫游泳试验。
测量与结果
作为抑郁行为参数，CLP处理动物在强迫游泳试验中观察到的不动时间增加被丙咪嗪逆转。
结论
给予丙咪嗪后，通过强迫游泳试验评估的抑郁症状得到逆转。我们的数据提供了证据表明CLP诱导的抑郁症状对抗抑郁药敏感。
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