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依托咪酯、丙泊酚和戊巴比妥对人5-羟色胺（3A）和5-羟色胺（3AB）受体的抑制作用。

Inhibition of human 5-HT(3A) and 5-HT(3AB) receptors by etomidate, propofol and pentobarbital.

作者信息

Rüsch Dirk, Braun Hans A, Wulf Hinnerk, Schuster Anika, Raines Douglas E

机构信息

Department of Anaesthesia and Critical Care, University Hospital Giessen-Marburg GmbH, Marburg Campus, Baldingerstrasse, 35033 Marburg, Germany.

出版信息

Eur J Pharmacol. 2007 Nov 14;573(1-3):60-4. doi: 10.1016/j.ejphar.2007.07.009. Epub 2007 Jul 13.

DOI:10.1016/j.ejphar.2007.07.009
PMID:17669396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2276611/
Abstract

The actions of intravenous anaesthetics on 5-HT(3AB) receptors have not been studied. Using oocyte electrophysiology, the effects of etomidate, propofol, and pentobarbital on human 5-HT(3A) and 5-HT(3AB) receptors were studied and compared. Inhibition of peak currents by all three compounds in both receptor subtypes was anaesthetic concentration-dependant and non-competitive. Because the half-maximal inhibitory concentrations for etomidate, propofol and pentobarbital in 5-HT(3A) and 5-HT(3AB) receptors were all above their respective anaesthetic concentrations, the results of our study suggest that neither 5-HT(3) receptor subtype contributes to the anaesthetic actions of etomidate, propofol or pentobarbital.

摘要

静脉麻醉药对5-HT(3AB)受体的作用尚未得到研究。运用卵母细胞电生理学方法，研究并比较了依托咪酯、丙泊酚和戊巴比妥对人5-HT(3A)和5-HT(3AB)受体的影响。这三种化合物对两种受体亚型的峰值电流的抑制作用均呈麻醉浓度依赖性且为非竞争性。由于依托咪酯、丙泊酚和戊巴比妥在5-HT(3A)和5-HT(3AB)受体中的半数最大抑制浓度均高于其各自的麻醉浓度，我们的研究结果表明，5-HT(3)受体亚型均不参与依托咪酯、丙泊酚或戊巴比妥的麻醉作用。

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