[使用六肽毒素联合抗代谢物甲氨蝶呤提高伤寒疫苗的辐射防护治疗效果]
[Increasing the radioprotective therapeutic efficacy of typhoid vaccine using sexta-anatoxin in combination with the antimetabolite methotrexate].
作者信息
Deshevoĭ Iu B, Martirosov K S, Andrianova I E
出版信息
Radiobiologiia. 1991 Nov-Dec;31(6):853-5.
PMID:1767016
Abstract
A typhoid vaccine with sexta-anatoxin delivered to mice 4.5-5 h after gamma-irradiation has a pronounced therapeutic effect: survival rate is 42% with radiation dose of 8.2 Gy (LD85/30) and 19% with radiation dose of 8.7 Gy (LD95/30). The vaccine of 2.5 and 5 mg/kg combined with methotrexate has a more pronounced therapeutic effect increasing the survival rate up to 65% (LD85/30) and up to 35-40% (LD95/30).
摘要
在γ射线照射后4.5 - 5小时给小鼠接种含有六价类毒素的伤寒疫苗具有显著的治疗效果：辐射剂量为8.2戈瑞（LD85/30）时生存率为42%，辐射剂量为8.7戈瑞（LD95/30）时生存率为19%。2.5毫克/千克和5毫克/千克的疫苗与甲氨蝶呤联合使用具有更显著的治疗效果，将生存率提高至65%（LD85/30）和35 - 40%（LD95/30）。
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