Shrivastava Vivek, Nyawo Brian, Dunning Joel, Morritt Graham
Department of Cardiothoracic Surgery, James Cook University Hospital, Marton Road, Middlesbrough, UK.
Interact Cardiovasc Thorac Surg. 2004 Dec;3(4):656-62. doi: 10.1016/j.icvts.2004.08.002.
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed whether prophylactic anti-arrhythmic drugs may prevent atrial fibrillation (AF) following lung resection. Altogether 457 papers were found using the reported search, of which 14 presented the best evidence to answer the clinical question. The author, journal, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. We identified single randomized trials that have demonstrated a benefit for Diltiazem, Bupivacaine epidural and magnesium for prophylaxis against AF in patients undergoing non-cardiac thoracic surgery, with a number needed to treat of between 4 and 8 with these regimes.
根据结构化方案撰写了一篇胸外科最佳证据主题文章。该问题探讨预防性抗心律失常药物是否可预防肺切除术后房颤（AF）。通过报告的检索共找到457篇论文，其中14篇提供了回答该临床问题的最佳证据。这些论文的作者、期刊、发表日期和国家、研究的患者群体、研究类型、相关结局、结果及研究不足均列于表格中。我们确定了单项随机试验，这些试验表明地尔硫䓬、布比卡因硬膜外给药和镁对非心脏胸科手术患者预防房颤有益，采用这些方案治疗所需的患者数为4至8例。
