Omorphos Savvas, Hanif Mohammed, Dunning Joel
Department of Cardiothoracic Surgery, Freeman Hospital, Freeman Road, Newcastle Upon Tyne NE7 7AZ, UK.
Interact Cardiovasc Thorac Surg. 2004 Dec;3(4):641-6. doi: 10.1016/j.icvts.2004.07.014.
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether prophylactic beta-blockers effectively reduces the incidence of atrial fibrillation post-cardiac surgery. Altogether 113 papers were found using the reported search, of which 8 represented the best evidence on this topic. The author, journal, date and country of publication, patient group studied, study type, relevant outcomes, results, and study weaknesses were tabulated. We conclude that prophylactic beta-blockers clearly reduce the incidence of AF with a number needed to treat of only seven to prevent one episode of AF. The optimal beta-blocker or the benefits to patients with impaired ejection fraction are less clear.
根据结构化方案撰写了一篇心脏外科领域的最佳证据主题文章。所探讨的问题是预防性使用β受体阻滞剂是否能有效降低心脏手术后房颤的发生率。通过报告的检索共找到113篇论文，其中8篇代表了关于该主题的最佳证据。将作者、期刊、出版日期和国家、所研究的患者群体、研究类型、相关结局、结果以及研究的不足之处制成表格。我们得出结论，预防性使用β受体阻滞剂可明显降低房颤发生率，仅需治疗7例患者就能预防1例房颤发作。最佳β受体阻滞剂或对射血分数受损患者的益处尚不清楚。
