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电视辅助胸腔镜肺叶切除术与传统开胸肺叶切除术治疗临床ⅠA期非小细胞肺癌的对比研究

Video-assisted thoracoscopic lobectomy vs. conventional lobectomy via open thoracotomy in patients with clinical stage IA non-small cell lung carcinoma.

作者信息

Sakuraba Motoki, Miyamoto Hideaki, Oh Shiaki, Shiomi Kazu, Sonobe Satoshi, Takahashi Nobumasa, Imashimizu Kota, Sakao Yukinori

机构信息

Department of General Thoracic Surgery, Juntendo University, School of Medicine, Hongo 2-1-1 Bunkyo-ku, Tokyo, 113-8421, Japan.

出版信息

Interact Cardiovasc Thorac Surg. 2007 Oct;6(5):614-7. doi: 10.1510/icvts.2007.157701. Epub 2007 Jul 26.

Abstract

The aim of this study was to evaluate our personal experience with video-assisted thoracoscopic lobectomy and compare survival between this procedure and conventional lobectomy via open thoracotomy in patients with clinical stage IA non-small cell lung carcinoma. Between May 1997 and December 2004, 140 patients with clinical stage IA non-small cell lung carcinoma had either VATS lobectomy (VATS group, 84 patients) or standard lobectomy via open thoracotomy (open group, 56 patients) performed in our hospital. We compared overall survival, disease-free survival and recurrence between the two groups. The overall survival rate five years after surgery was 72% in the open group and 82% in the VATS group. There were no significant differences in the overall survival rate between the two groups. The disease-free survival rate five years after surgery was 68% in the open group and 80% in the VATS group. There were no significant differences in the disease-free survival rate between the two groups. Five patients in the open group developed distant recurrence, whereas one patient developed regional recurrence. In the VATS group six patients developed distant recurrence, whereas one patient developed regional recurrence. We consider VATS lobectomy to be one of the therapeutic options in patients with clinical stage IA non-small cell lung carcinoma.

摘要

本研究旨在评估我们在电视辅助胸腔镜肺叶切除术方面的个人经验,并比较该手术与传统开胸肺叶切除术治疗临床ⅠA期非小细胞肺癌患者的生存率。1997年5月至2004年12月期间,140例临床ⅠA期非小细胞肺癌患者在我院接受了电视辅助胸腔镜肺叶切除术(电视辅助胸腔镜组,84例患者)或标准开胸肺叶切除术(开胸组,56例患者)。我们比较了两组患者的总生存率、无病生存率和复发情况。开胸组术后五年总生存率为72%,电视辅助胸腔镜组为82%。两组总生存率无显著差异。开胸组术后五年无病生存率为68%,电视辅助胸腔镜组为80%。两组无病生存率无显著差异。开胸组有5例患者发生远处复发,1例患者发生局部复发。电视辅助胸腔镜组有6例患者发生远处复发,1例患者发生局部复发。我们认为电视辅助胸腔镜肺叶切除术是临床ⅠA期非小细胞肺癌患者的治疗选择之一。

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